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KMID : 0367420050480101126
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Journal of Korean Pediatric Society
2005 Volume.48 No. 10 p.1126 ~ p.1131
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Relationship between △FVC(% fall in FVC at the PC20 Dose of Methacholine) and Serum Eosinophil Cationic Protein(ECP) in 6-8 Year Old Children with Asthma
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Suh Dong-In
Yu Jin-Ho
Yoo Young
Kim Do-Kyun
Kang Hee
Koh Young-Yull
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Abstract
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Purpose: Bronchial hyperresponsiveness(BHR) is considered a hallmark of asthma. Increased levels of eosinophil cationic protein(ECP) have been identified in serum of asthma patients. Several studies have examined the relationship between serum ECP and bronchial responsiveness, expressed as methacholine PC20 in asthmatic patients, with conflicting results. The aims of this study were to examine the relationship between serum ECP and deltaFVC, another index of bronchial responsiveness, which reflects increased maximal airway response.
Methods: Six to 8-year-old children with asthma(n=109) underwent methacholine bronchoprovocation testing. The PC20 dose of methacholine and deltaFVC were calculated for each individual from the methacholine dose response curves. Serum ECP levels and blood total eosinophil counts were also measured.
Results: Serum ECP correlated with deltaFVC(r=0.217, P=0.023), as well as PC20(r=-0.208, P=0.030). However, blood eosinophil counts failed to show any correlations with deltaFVC(r=0.085, P=0.378) or PC20(r=-0.148, P=0.125). deltaFVC did not correlate with PC20(r=-0.079, P=0.417).
Conclusion: Blood eosinophil activation is associated with both components of BHR including increased sensitivity and increased maximal response in 6-8 year old children with asthma.
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KEYWORD
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Bronchial hyperresponsiveness, △FVC, PC20, Serum ECP, Asthma, Children
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